Castor oil emulsion formulation:-
What is an emulsion?
A mixture of two or more immiscible substances made miscible with the help of emulsifying agents (e.g. gum acacia).
Types of emulsion:-
- Oil in water:- if oil is dispersed in water, e.g. milk
- Water in oil-if water droplets are added to oil, e.g. margarine, castor oil emulsion etc.
Castor oil emulsion:-
Oleum ricini 1.0 ml
Gum acacia 1.5 gms
Aqua ad 16.0 ml
M.ft. emulsion one, send three such.
One does to be taken daily in the early morning.
Castor oil emulsion Procedure:-
- Take 4.5 gms of gum acacia and put in the mortar.
- Take 3 ml of oleum ricini in a measuring flask and add drop by drop to the gum acacia in the mortar.
- Mix the two substances by continuous grinding with the help of the pestle.
- Add water drop by drop until a milky white emulsion is prepared and no air or water bubble are seen in the emulsion.
- Then transfer the preparation to the measuring flask and add more water was to make the final volume of the preparation to 48 ml.
- Transfer this emulsion to the dispensing bottle, label it and cork it.
- Put a scale on the other side for proper dosing.
Castor oil emulsion mechanism of action:-
- It is one of the oldest purgatives to be used.
- It is a vegetable oil obtained from the seeds of Ricinus communis.
- After ingestion, castor oil reaches the ileum.
- Here, it is hydrolyzed to ricinoleic acid(active principle) and glycerol by pancreatic lipase.
- Ricinoleic acid is polar, hence poorly absorbed and irritates the mucosa, stimulating intestinal contractions.
- It also decreases intestinal absorption of water and electrolytes and enhances secretion by a detergent-like action on the mucosa.
- DOSE: 15-25 ml(adults), 5-15 ml(children) taken in the morning.
- ONSET OF ACTION:2-3 hours
Castor oil emulsion uses:-
- As a stimulant purgative
- Hair oil
- Possibility of dehydration
- After-constipation following prolonged use.
- Acute abdominal pain.
- Acute appendicitis.
- Intestinal perforation
Prevention of constipation:-
- High fiber diet.
- Adequate wats intake.
- Regular exercise.
- Heeding of nature’s call.
- Avoidance of self-medication
Other drug use in constipation:-
- Bulk-forming:- dietary fibers, bran, psillium, ispaghula, methylcellulose.
- Stool softener:- docussates(DOSS), liquid paraffin, glycerine suppositories.
- Other stimulant purgatives:- bisacodyl, senna, cascara, prucalopride, tegaserod etc.
- Osmotic purgatives:- sulfate and hydroxide salts of magnesium hydroxide and phosphate of sodium, sodium potassium tartrate, sorbitol, lactulose, balanced PEG (polyethylene glycol).
- Chloride channel activators:- Lubiprostone, Linaclotide
- Opioid receptor antagonist:- Methyl naltrexone, Alvimopan